CloneID: h130M23-H1L2
Antigen Long Description: The antibody is the humanized version of the murine 130M23.
Buffer Composition: PBS with 0.02% Proclin 300.
Available Custom Conjugation Options: AP, HRP, Fluorescein, APC, PE, Biotin Type A, Biotin Type B, Streptavidin, FluoroProbes 647H, Atto488, APC/Cy7, PE/Cy7
Uniprot Accession No.: Q6UXX9
Specificity Statement: The antibody specifically reacts with human and mouse RSPO2.
Application Notes (Clone): The antibody was shown to completely block β-catenin signaling, demonstrating it is a specific inhibitor of RSPO2. The antibody blocked soluble RSPO2 binding to LGR5. The antibody had a binding affinity for human RSPO2 of 0.14 nM and mouse RSPO2 of 0.35 nM. The antibody demonstrated strong anti-tumor growth activity in combination with gemcitabine in a pancreatic xenograft model and inhibition of pancreatic tumor growth in vivo as a single agent and in combination with additional therapeutic agents. The humanized version of the antibody was produced. The humanized version had a binding affinity for human RSPO2 of 0.13 nM (US8802097B2).
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