CloneID: Fab-8-1
Heavy Chain modification: Fc Silent™
Antigen Long Description: Human TDRD3.
Buffer Composition: PBS only.
Chimeric Use Statement: This full-length, chimeric mouse antibody was made using the variable domain sequences of the original Human scFv format, for improved compatibility with existing reagents, assays and techniques.
Uniprot Accession No.: Q9H7E2
Specificity Statement: Binds to human TDRD3 with a Kd-value of 1 nM. Specificity checked by ELISA - it show no binding to any of 13 non-cognate antigens.
Application Notes (Clone): This antibody binds to the tudor domain of TDRD3, a nuclear coactivator that recognizes and binds asymmetric dimethylation on the core histone tails associated with transcirptional activation such as H4R3me2 or H3R17me2. In the cytoplasm, it is suggested to be involved in the assembly and disassembly of mRNA stress granules. Interesting feature about this antibody: The CDR-H3 plays virtually no role in antigen recognition.
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