CloneID: 8E11
Heavy Chain modification: Fc Silent™
Antigen Long Description: The original antibody was generated by immunizing 6-8 weeks old female BALB/c mice with recombinant human TIM-3 protein.
Buffer Composition: PBS with 0.02% Proclin 300.
Chimeric Use Statement: This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format for improved compatibility with existing reagents assays and techniques.
Available Custom Conjugation Options: AP, HRP, Fluorescein, APC, PE, Biotin Type A, Biotin Type B, Streptavidin, FluoroProbes 647H, Atto488, APC/Cy7, PE/Cy7
Uniprot Accession No.: Q8TDQ0
Specificity Statement: This antibody binds human TIM-3. Hepatitis A virus cellular receptor 2 (HAVCR2), also known as T-cell immunoglobulin and mucin-domain containing-3 (TIM-3), is a protein expressed on the cell surface of IFNγ producing CD4+ Th1 and CD8+ Tc1 cells. This protein is also expressed on the surface of Th17 cells, regulatory T-cells and innate immune cells like dendritic cells, NK cells and monocytes. It is a cell surface receptor implicated in modulating innate and adaptive immune responses.
Application Notes (Clone): This antibody can be used in the detection of human TIM-3 using ELISA. The binding characterization of this antibody for human TIM-3 was done using indirect immunofluorescence labelling and flow cytometry (CN106632675).
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