CloneID: ABDD073
Heavy Chain modification: Fc Silent™
Antigen Long Description: The original antibody was generated by immunizing BALB/C mice with VEGFR-3/Ig recombinant protein.
Buffer Composition: PBS only.
Chimeric Use Statement: This is a reformatted human IgG1 Fc Silent™ antibody, based on the original human IgG2a format, created for improved compatibility with existing reagents, assays and techniques.
Uniprot Accession No.: P35916
Specificity Statement: The antibody is specific for VEGFR-3.
Application Notes (Clone): The antibody showed neutralizing activity by ELISA analysis. The antibody detected VEGFR-3 from HEL cell lysates by western blot analysis. The antibody could recognize VEGRF-3 on fetal heart, fetal kidney and fetal lung tissue by immunohistochemistry. The binding activity of the antibody to VEGFR-3 expressed on the surface of HEL cells was confirmed by FACS flow cytometry. In vitro experiments showed the antibody could block the interaction between VEGFR-3 and VEGF-D. The antibody could inhibit HEL cell proliferation. The antibody could inhibit the generation of chicken embryo allantoic membrane blood vessels induced by recombinant GST-VEGF-D (CN1800373A).
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