Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: 3-[4-(2-chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-2-yl]-1-(4-morpholinyl)-1-propanone
Purity: ≥98%
Formula Markup: C22H22ClN5O2S
Formula Weight: 456.0
CAS Number: 105219-56-5
Notes: Platelet-activating factor (PAF) is a biologically active phospholipid that activates platelets, polymorphonuclear leukocytes, monocytes, and macrophages.{939} PAF also increases vascular permeability, decreases cardiac output, induces hypotension, stimulates uterine contraction, and has been implicated in pathological processes, such as inflammation and allergy.{11753} Apafant is a water soluble, selective PAF receptor antagonist that inhibits PAF binding to human PAF receptors with a Ki value of 9.9 nM.{22980} Apafant displays anti-inflammatory, antiangiogenic, and anticancer activity.{22980,22981,16870}
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