Clone Name: ARC53932
Application Note: WB: 1:500-1:1000. IHC-P: 1:50-1:200. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Calculated MW: 312
Form: Liquid
Buffer (with preservative): PBS, 0.05% BSA, 50% Glycerol, 0.05% Proclin300.
Concentration: Batch dependent (Please refer to the vial label for the specific concentration.)
Background: This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. [provided by RefSeq, Jul 2008]
Uniprot ID: P25054
Antigen Species: Human
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 2600-2760 of human APC (NP_000029.2).
Purification: Purified by affinity chromatography
Conjugation: Unconjugated
Full Name: APC regulator of WNT signaling pathway
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