Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 5,7-dihydroxy-2-(4-hydroxyphenyl-3,5-d2)-4H-1-benzopyran-4-one-3,6,8-d3
Purity: ≥99% deuterated forms (d1-d5); ≤1% d0
Formula Markup: C15H5D5O5
Formula Weight: 275.3
CAS Number: 263711-74-6
Notes: Apigenin-d5 is an internal standard for the quantificaiton of apigenin (Item No. 10010275) by GC- or LC-MS. Apigenin is a flavonoid compound found in many fruits and vegetables that selectively inhibits casein kinase 2 (CK2). Apigenin inhibits CK2 activity in the renal cortex with an IC50 value of 30 µM to improve renal function in a rat model of glomerulonephritis.{15364} CK2 inhibition by 20 µM apigenin decreases the degradation of IκBα and down-regulates NF-κB levels in WEHI-231 cells.{15361} Apigenin, at 5 µM, is a potent inhibitor of the synthesis of the inflammatory mediators nitric oxide and prostaglandin E2, reducing inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression by 56% and 64%, respectively, in the macrophage cell line J774A.1.{15362}
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