Product Description: Arglabin ((+)-Arglabin), a natural product isolated from Artemisia glabella, is a NLRP3 inflammasome inhibitor. Arglabin shows anti-inflammatory and antitumor activities[1]. The antitumor activity of Arglabin proceeds through its inhibition of farnesyl transferase which leads to the activation of RAS proto-oncogene[2].
Applications: Cancer-programmed cell death
Formula: C15H18O3
References: [1]Abderrazak A, et al. Anti-inflammatory and antiatherogenic effects of the NLRP3 inflammasome inhibitor arglabin in ApoE2.Ki mice fed a high-fat diet. Circulation. 2015;131(12):1061-1070./[2]Lone SH, et al. Arglabin: From isolation to antitumor evaluation. Chem Biol Interact. 2015;240:180-198.
CAS Number: 84692-91-1
Molecular Weight: 246.306
Compound Purity: 99.87
Research Area: Cancer; Inflammation/Immunology
Solubility: DMSO : ≥ 100 mg/mL
Target: Autophagy;Farnesyl Transferase;NOD-like Receptor (NLR)
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