ARV-471, CAS 2229711-68-4

Shelf life (days): 1460.0

Formulation: A solid

Formal Name: (3S)-3-[1,3-dihydro-1-oxo-5-[4-[[1-[4-[(1R,2S)-1,2,3,4-tetrahydro-6-hydroxy-2-phenyl-1-naphthalenyl]phenyl]-4-piperidinyl]methyl]-1-piperazinyl]-2H-isoindol-2-yl]-2,6-piperidinedione

Purity: ≥98%

Formula Markup: C45H49N5O4

Formula Weight: 723.918

CAS Number: 2229711-68-4

Notes: A PROTAC that drives ER degradation; induces degradation of ER in MCF-7 cells (DC50 = 0.9 nM); inhibits the growth of T47D and MCF-7 cells expressing wild-type ER (GI50s = 4.5 and 3.3 nM, respectively) and T47D cells expressing ERY537S or ERD538G mutations (GI50s = 8 and 5.7 nM, respectively); reduces tumor growth in an MCF-7 orthotopic mouse xenograft model at 3, 10, and 30 mg/kg per day; induces tumor regression in a PDX ERY537S-expressing mouse model of breast cancer at 10 and 30 mg/kg

• Artikelnummer: CAY43002-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 43002-5
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK