Product Description: Ascomycin (Immunomycin; FR-900520; FK520) is an ethyl analog of Tacrolimus (FK506) with strong immunosuppressant properties. Ascomycin is also a macrocyclic polyketide antibiotic with multiple biological activities such as anti-malarial, anti-fungal and anti-spasmodic. Ascomycin prevents graft rejection and has potential for varying skin ailments research[1][2].
Applications: COVID-19-immunoregulation
Formula: C43H69NO12
References: [1]Hatanaka H, et al. FR-900520 and FR-900523, novel immunosuppressants isolated from a Streptomyces. II. Fermentation, isolation and physico-chemical and biological characteristics. J Antibiot (Tokyo). 1988 Nov;41(11):1592-601./[2]Krishika Sambyal, et al. Bioprocess and genetic engineering aspects of ascomycin production: a review. J Genet Eng Biotechnol. 2020 Nov 19;18(1):73./[3]Germán Sierra-Paredes, et al. Ascomycin and FK506: pharmacology and therapeutic potential as anticonvulsants and neuroprotectants. CNS Neurosci Ther. Spring 2008;14(1):36-46.
CAS Number: 104987-12-4
Molecular Weight: 792.01
Compound Purity: 99.62
Research Area: Infection; Inflammation/Immunology; Neurological Disease
Solubility: DMSO : ≥ 39 mg/mL
Target: Antibiotic;FKBP;Fungal;Parasite
Deutsch
English
