Shelf life (days): 365.0
Formulation: PBS, pH 7.5, with 20% glycerol
Uniprot ID: Q9UBL3
Purity: ≥70%
Formula Weight: 0.0
Notes: ASH2-like, histone lysine methyltransferase complex subunit (ASH2L) is a member of the trithorax group (TrxG) of proteins and an obligatory component of all histone H3K4 activating methylation complexes, also known as COMPASS complexes.{19552,19554,51876} It is ubiquitously expressed and composed of a PHD finger, a WH motif, an SPRY domain, and a dpy-30 histone methyltransferase complex regulatory subunit (DPY30) binding motif.{51875,51874} ASH2L, in conjunction with WD repeat domain 5 (WDR5), RB-binding protein 5 (RBBP5), and DPY30, optimizes the methyltransferase activity of histone-lysine N-methyltransferase SET enzymes within COMPASS complexes and has roles in epigenetic regulation and neurogenesis.{51876} Global knockdown of Ash2l induces early embryonic lethality in mice. Dorsal ectoderm-targeted knockdown of ash2l in late, but not early, Xenopus neurula embryos inhibits neural and neural crest marker gene expression. ASH2L levels are increased in acute myeloid leukemia (AML) cells isolated from patients with mutant FMS-related tyrosine kinase 3 (FLT-3) compared with those isolated from patients with wild-type FLT-3, and lower levels of ASH2L are positively correlated with increased overall survival.{51874} Cayman’s ASH2L (human, recombinant) protein can be used for Western blot (WB) applications.
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