Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: (4a)-2a,3ß,23-trihydroxy-urs-12-en-28-oic acid
Purity: ≥95%
Formula Markup: C30H48O5
Formula Weight: 488.7
CAS Number: 464-92-6
Notes: Asiatic acid is a pentacyclic triterpene isolated from a variety of plants, including C. asiatica, used in traditional medicines. In addition to anti-inflammatory actions, asiatic acid stimulates wound healing by increasing collagen production.{22102} It has also been found to induce cell cycle arrest and apoptosis in breast cancer cells (IC50 = 5.9 µM for MCF-7 cells) and block angiogenesis in cells and tumors from glioblastomas.{22275,22276} Asiatic acid also impacts amyloid-β precursor protein processing by down regulating BACE1 while increasing ADAM10 maturation in primary rat cortical neurons.{22277} In addition, it reduces neuronal damage and cognitive defects resulting from glutamate administration in vivo in mice while demonstrating protective effects against glutamate-induced apoptosis in isolated SH-SY5Y cells.{22274}
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