AT-9283, CAS 896466-04-9

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: N-cyclopropyl-N'-[3-[6-(4-morpholinylmethyl)-1H-benzimidazol-2-yl]-1H-pyrazol-4-yl]-urea

Purity: ≥98%

Formula Markup: C19H23N7O2

Formula Weight: 381.4

CAS Number: 896466-04-9

Notes: AT-9283 is a broad spectrum kinase inhibitor that potently inhibits Aurora A, Aurora B, JAK2, JAK3, and c-ABL (IC50s = 3, 3, 1.2, 1.1, and 4 nM, respectively).{24830} It also potently (IC50 = receptor tyrosine kinases.{24830} As Aurora kinases have roles in mitosis, inhibitors of these kinases, including AT-9283, have potential in cancer therapy.{24832} Consistent with this, AT-9283 is effective in preventing proliferation of cancer cells both in vitro and in vivo and this effect may be enhanced by combination therapy with other chemotherapeutics.{24831,24829}

• Artikelnummer: CAY11496-25
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 11496-25
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK