Product Description: AT7867 is a potent ATP-competitive inhibitor of Akt1/Akt2/Akt3 and p70S6K/PKA with IC50s of 32 nM/17 nM/47 nM and 85 nM/20 nM, respectively.
Applications: Cancer-Kinase/protease
Formula: C20H20ClN3
References: [1]Grimshaw KM, et al. AT7867 is a potent and oral inhibitor of AKT and p70 S6 kinase that induces pharmacodynamic changes and inhibits human tumor xenograft growth. Mol Cancer Ther, 2010, 9(5), 1100-1110.
CAS Number: 857531-00-1
Molecular Weight: 337.85
Compound Purity: 99.88
Research Area: Cancer
Solubility: DMSO : 50 mg/mL (ultrasonic;warming;heat to 60°C)
Target: Akt;PKA;Ribosomal S6 Kinase (RSK)