Target: ATG4B
Conjugate: ATTO 390
Product Type: Polyclonal
Immunogen: Synthetic peptide from the N-terminal to mid of Human ATG4B (aa. 94-106)
Swiss-Prot: Q9Y4P1
Purification: Peptide Affinity Purified
Storage Buffer: 640.91mM DMSO, 136.36mM Ethanolamine, and 9.09mM Sodium Bicarbonate in 90.9% PBS
Concentration: 1 mg/ml
Specificity: Detects ~44 kDa.
Cellular Localization: Cytoplasm
Tissue Specificity: Mainly expressed in the skeletal muscle, followed by brain, heart, liver and pancreas.
Scientific Background: Autophagy related 4B, cysteine peptidase (ATG4B or APG4B) is a C-54 cysteine protease that also belongs to the family of autophagin poteins. Specifically it cleaves LC3, and mutations can be associated with strong inhibition of autophagosome formation.
References: 1. Kabeya Y., et al. (2004) J Cell Sci. 117: 2805-2812.2. Tanida I., et al. (2004) J Biol Chem. 279: 36268-36276.3. Hemelaar J., et al. (2003) J Biol Chem. 278: 51841-51850.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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