Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 4,4aS,5,6,7,8,8aR,9-octahydro-3,8a-dimethyl-5-methylene-naphtho[2,3-b]furan
Purity: ≥95%
Formula Markup: C15H20O
Formula Weight: 216.3
CAS Number: 6989-21-5
Notes: A sesquiterpene with diverse biological activities; scavenges DPPH radicals in a cell-free assay at 0.01, 0.1, or 1 mg/ml; antagonist of dopamine D2 receptors (IC50 = 2.5 µM); inhibitor of 5-LO; (IC50 = 25.1 µM); inhibits tert-butyl hydroperoxide-induced release of ALT and LDH and increases in intracellular MDA and DNA damage in primary rat hepatocytes; induces apoptosis and disrupts the mitochondrial membrane potential in HepG2 and MHCC97H cells at 5, 10, or 20 µM; inhibits migration and invasion, decreases the levels of α-SMA, vimentin, N-cadherin, MMP-2, MMP-9, and increases E-cadherin and TIMP-2 in the same cells; decreases tumor volume and weight in a HepG2 mouse xenograft model at 5 or 10 mg/kg per day; increases the number of striatal dopamine receptor-positive neurons and decreases gait impairment in a mouse model of MPTP-induced Parkinson's disease
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