AVL-292, CAS 1202757-89-8

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: N-[3-[[5-fluoro-2-[[4-(2-methoxyethoxy)phenyl]amino]-4-pyrimidinyl]amino]phenyl]-2-propenamide

Purity: ≥98%

Formula Markup: C22H22FN5O3

Formula Weight: 423.4

CAS Number: 1202757-89-8

Notes: AVL-292 is a covalent inhibitor of Bruton’s tyrosine kinase (BTK; IC50 = 5.9 nM).{30733} It is selective for BTK over a panel of 61 kinases when used at a concentration of 1 µM but does inhibit the additional Tec family kinases BMX, Itk, Tec, and TXK (IC50s = 0.7, 36, 6.2, and 8.9 nM, respectively). AVL-292 inhibits naïve human B cell proliferation (EC50 = 3 nM). It reduces joint damage, pannus formation, cartilage degradation, and bone erosion in a mouse model of rheumatioid arthritis induced by collagen when used at doses of 3, 10, and 30 mg/kg.

• Artikelnummer: CAY17993-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 17993-1
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK