Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 1-[4-(1,1-dimethylethyl)phenyl]-3-[4-(methoxy-13C-d3)phenyl]-1,3-propanedione
Purity: ≥99% deuterated forms (d1-d3)
Formula Markup: C19[13C]H19D3O3
Formula Weight: 314.4
CAS Number: 2933758-47-3
Notes: Avobenzone-13C-d3 is intended for use as an internal standard for the quantification of avobenzone (Item No. 23836) by GC- or LC-MS. Avobenzone is a full-spectrum ultraviolet A (UVA) blocker.{41451} It inhibits UVA-induced increases in melanin levels and tyrosinase activity in B16/F10 melanoma cells (IC30s = 21.94 and 24.25 μM, respectively).{41452} Avobenzone (30 μM) also inhibits UVA-induced production of reactive oxygen species (ROS) and 8-hydroxy-2'-deoxyguanosine (8-OH-dG; Item No. 89320), as well as inhibits UVA-induced depletion of glutathione (GSH), in B16/F10 cells. It increases nuclear translocation of nuclear factor erythroid 2-related factor 2 (Nrf2) and upregulates the antioxidant response element (ARE) in UVA-irradiated B16/F10 cells when used at at a concentration of 30 μM. Formulations containing avobenzone have been used as sun protectants in sunscreen products.
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