AY 9944, CAS 366-93-8

AY 9944, CAS 366-93-8
Artikelnummer
MEXHY-107420-50
Verpackungseinheit
50 mg
Hersteller
MedChemExpress

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Product Description: AY 9944 is a specific cholesterol biosynthesis inhibitor. AY 9944 inhibits the 7-dehydro cholesterol Δ7-reductase (DHCR7) enzyme with an IC50 of 13 nM. AY 9944 causes hypocholesterolemia and accumulation of 7DHC. At high doses, AY 9944 inhibits also in cultured embryos sterol Δ7-Δ8 isomerase, which causes the accumulation of cholest-8-en-3β-ol[1][2][3].

Applications: Metabolism-protein/nucleotide metabolism

Formula: C22H30Cl4N2

References: [1]Moebius FF, et al. Molecular cloning and expression of the human delta7-sterol reductase. Proc Natl Acad Sci U S A. 1998 Feb 17;95(4):1899-902./[2]Nemanic MK, et al. In vitro synthesis of vitamin D-3 by cultured human keratinocytes and fibroblasts: action spectrum and effect of AY-9944. Biochim Biophys Acta. 1985 Sep 6;841(3):267-77./[3]Cortez MA, et al. Brain sterols in the AY-9944 rat model of atypical absence seizures. Epilepsia. 2002 Jan;43(1):3-8.

CAS Number: 366-93-8

Molecular Weight: 464.30

Compound Purity: 99.67

Research Area: Metabolic Disease

Solubility: DMSO : 5 mg/mL (ultrasonic)/H2O : 5 mg/mL (ultrasonic)

Target: Others
Mehr Informationen
Artikelnummer MEXHY-107420-50
Hersteller MedChemExpress
Hersteller Artikelnummer HY-107420-50
Verpackungseinheit 50 mg
Mengeneinheit STK
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