AZ'3137, CAS 2960179-55-7

Product Description: AZ‘3137 is an orally active PROTAC-type androgen receptor (AR) degrader with a DC50 value of 22 nM. AZ‘3137 can degrade L702H mutant AR (DC50 of 92 nM). AZ'3137 can inhibit cell proliferation of LNCaP, with a GI50 value of 74 nM. AZ'3137 can inhibit AR signaling and tumor growth in prostate cancer mice (Pink: AR Ligand (HY-172954); Blue: CRBN ligand (HY-172955); Black: linker (HY-W262798); E3 Ligand+Linker: HY-172956)[1].

Applications: Cancer-programmed cell death

Formula: C43H47F4N7O4

References: [1]Bagal SK, et al. Discovery of a Series of Orally Bioavailable Androgen Receptor Degraders for the Treatment of Prostate Cancer. J Med Chem. 2024 Jul 25;67(14):11732-11750.

CAS Number: 2960179-55-7

Molecular Weight: 801.87

Compound Purity: 99.90

Research Area: Cancer

Solubility: DMSO : 50 mg/mL (ultrasonic)

Target: Androgen Receptor;PROTACs

• Artikelnummer: MEXHY-162702-5
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-162702-5
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK