AZ 32, CAS 2288709-96-4

Shelf life (days): 1460.0

Formulation: A solid

Formal Name: N-methyl-4-(6-phenylimidazo[1,2-a]pyrazin-3-yl)-benzamide

Purity: ≥98%

Formula Markup: C20H16N4O

Formula Weight: 328.3674

CAS Number: 2288709-96-4

Notes: AZ 32 is an inhibitor of ataxia-telangiectasia mutated (ATM) kinase (IC50 = 50s = 4.6 and >4.6 µM, respectively). AZ 32 enhances radiation-induced cytotoxicity in a panel of five human glioma cells expressing wild-type or mutant p53. It increases survival in a U87-281G glioma orthotopic mouse xenograft model, as well as a NCI H2228 non-small cell lung cancer (NSCLC) mouse xenograft model of metastatic brain tumors, when administered at doses of 200 and 50 mg/kg, respectively, in combination with ionizing radiation.

• Artikelnummer: CAY26380-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 26380-5
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK