AZD 1981, CAS 802904-66-1

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: 4-(acetylamino)-3-[(4-chlorophenyl)thio]-2-methyl-1H-indole-1-acetic acid

Purity: ≥98%

Formula Markup: C19H17ClN2O3S

Formula Weight: 388.9

CAS Number: 802904-66-1

Notes: AZD 1981 is a DP2/CRTH2 receptor antagonist (IC50 = 3.98 nM).{32940} It is selective for DP2 over a panel of receptors, ion channels, transporters, and enzymes, including DP1, COX-1, and COX-2, at 10 µM. AZD 1981 (3-100 nM) inhibits increases in the expression of CD11b, a cell adhesion molecule, induced by 13,14-dihydro-15-keto-prostaglandin D2 (13,14-dihydro-15-keto-PGD2; Item No. 12610) in isolated human eosinophils. It also inhibits 13,14-dihydro-15-keto-PGD2-induced chemotaxis of isolated human eosinophils and T cells in a concentration-dependent manner.

• Artikelnummer: CAY20763-50
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 20763-50
• Verpackungseinheit: 50 mg
• Mengeneinheit: STK