AZD 4320, CAS 1357576-48-7

Shelf life (days): 1460.0

Formulation: A solid

Formal Name: 4-[4-[(R)-(4'-chloro[1,1'-biphenyl]-2-yl)hydroxymethyl]-1-piperidinyl]-N-[[4-[[(1R)-3-[(2-hydroxyethyl)methylamino]-1-[(phenylthio)methyl]propyl]amino]-3-[(trifluoromethyl)sulfonyl]phenyl]sulfonyl]-benzamide

Purity: ≥98%

Formula Markup: C45H48ClF3N4O7S3

Formula Weight: 945.5

CAS Number: 1357576-48-7

Notes: An inhibitor of the Bcl-2-Bim and Bcl-xL-Bim protein-protein interactions (IC50s = 3.9 and 4.5 nM, respectively, in fluorescence polarization assays); induces apoptosis in MLL-AF9;NrasG12D mouse AML cells overexpressing human Bcl-2 or Bcl-xL but not Mcl-1, Bfl-1, or Bcl-W at 1 µM; induces apoptosis in wild-type but not Bax/Bak-/- SW48 cells; reduces tumor volume but induces transient thrombocytopenia in an RS4;11 ALL mouse xenograft model at 20 mg/kg

• Artikelnummer: CAY41978-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 41978-5
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK