Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 3-fluoro-5-[3-(5-fluoro-2-pyridinyl)-1,2,4-oxadiazol-5-yl]-benzonitrile
Purity: ≥98%
Formula Markup: C14H6F2N4O
Formula Weight: 284.220606
CAS Number: 327056-26-8
Notes: AZD 9272 is a brain-penetrant negative allosteric modulator of metabotropic glutamate receptor 5 (mGluR5; IC50 = 7.6 nM in a FLIPR calcium mobilization assay).{45717} It is selective for mGluR5 over mGluR1-4 and 6-8 in a FLIPR calcium mobilization assay (IC50s = >30 µM) and a panel of 134 receptors, ion channels, nuclear hormone receptors, transporters, and enzymes at 10 µM in radioligand binding assays.