Product Description: AZD8330 (ARRY-424704) is a potent, uncompetitive MEK1/MEK2 inhibitor, with an IC50 of 7 nM.
Applications: Cancer-Kinase/protease
Formula: C16H17FIN3O4
References: [1]Cohen RB, et al. A phase I dose-finding, safety and tolerability study of AZD8330 in patients with advanced malignancies. Eur J Cancer. 2013 May;49(7):1521-9./[2]Baranski Z, et al. MEK inhibition induces apoptosis in osteosarcoma cells with constitutive ERK1/2 phosphorylation. Genes Cancer. 2015 Nov;6(11-12):503-12.
CAS Number: 869357-68-6
Molecular Weight: 461.23
Compound Purity: 99.14
Research Area: Cancer
Solubility: DMSO : ≥ 100 mg/mL
Target: MEK