Product Description: Azido-PEG4-Val-Cit-PAB-MMAE is a agent-linker conjugate for ADC by using the anti-mitotic agent, monomethyl auristatin E (MMAE, a tubulin inhibitor), linked via the cleavable linker Azido-PEG4-Val-Cit-PAB-OH[1]. Azido-PEG4-Val-Cit-PAB-MMAE is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
Formula: C69H113N13O17
References: [1]Moreadith R, et, al. Polyoxazoline antibody drug conjugates. WO2016019340A1.
CAS Number: 1869126-64-6
Molecular Weight: 1396.71
Compound Purity: 99.36
Research Area: Cancer
Solubility: H2O : < 0.1 mg/mL (ultrasonic;adjust pH to 4 with 0.01 M Acetic acid)
Target: Drug-Linker Conjugates for ADC
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