Product Description: Azoramide is a potent, orally active small-molecule modulator of the unfolded protein response (UPR). Azoramide improves ER protein folding and elevates ER chaperone capacity, which together protects cells against ER stress. Azoramide alleviates PLA2G6 mutant-induced ER stress through modulating unfolded protein response, and enhances the CERB signaling to rescue mitochondrial function, thereby preventing apoptosis of DA neurons. Azoramide has antidiabetic activity[1][2].
Formula: C15H17ClN2OS
References: [1]Fu S, et, al. Phenotypic assays identify azoramide as a small-molecule modulator of the unfolded protein response with antidiabetic activity. Sci Transl Med. 2015 Jun 17;7(292):292ra98./[2]Ke M, et, al. Azoramide protects iPSC-derived dopaminergic neurons with PLA2G6 D331Y mutation through restoring ER function and CREB signaling. Cell Death Dis. 2020 Feb 18;11(2):130.
CAS Number: 932986-18-0
Molecular Weight: 308.834
Compound Purity: 99.72
Research Area: Endocrinology
Solubility: DMSO : ≥ 30 mg/mL
Target: Apoptosis;Bcl-2 Family;Caspase;Mitochondrial Metabolism;Reactive Oxygen Species
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