β-Glucuronidase Inhibitor, CAS 484006-66-8

Shelf life (days): 1460.0

Formulation: A solid

Formal Name: N-[(1,2-dihydro-6,8-dimethyl-2-oxo-3-quinolinyl)methyl]-N'-(4-ethoxyphenyl)-N-(2-hydroxyethyl-thiourea

Purity: ≥98%

Formula Markup: C23H27N3O3S

Formula Weight: 425.5

CAS Number: 484006-66-8

Notes: β-Glucuronidase inhibitor is an inhibitor of bacterial β-glucuronidase (IC50 = 283 nM for the E. coli enzyme).{51844} It inhibits wild-type but not Δ360-376 E. coli β-glucuronidase, a mutant lacking the bacteria-specific loop, when used at a concentration of 100 µM. In vivo, β-glucuronidase inhibitor (50 mg/kg) reduces colonic epithelial damage and the number of bloody diarrheal events induced by irinotecan (CPT-11) in a mouse model of chemotherapy-induced intestinal toxicity.

• Artikelnummer: CAY41228-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 41228-10
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK