B2M Knockout A549 Cell line

Products from BPS Bioscience require a minimum order value above 400€

Application: Study the impact of B2M knock-down.Study T cell activation, antigen presentation, and immune responses.

Background: Beta-2-Microglobulin is a required component of Major Histocompatibility Complex (MHC) class 1 molecules, which present peptide fragments from within the cell to cytotoxic T cells as part of the adaptive immune system. The protein forms amyloid fibrils in some pathological conditions. A mutation in this gene drives hypercatabolic hypoproteinemia. B2M plays an essential role both in governing MHC class I molecule stability and in promoting antigen binding and presenting the antigen to CD3/TCR complex of CD8+ T cells.

Description: B2M Knockout A549 Cell Line is an A549 cell line where B2M (Beta-2-Microglobulin) has been genetically removed by CRISPR/Cas9 genome editing.

Host Cell Line: A549 is a human lung alveolar vessel carcinoma cell line. Adherent epithelial cells.

Mycoplasma Testing: The cell line has been screened to confirm the absence of Mycoplasma species

Storage Stability: Cells are shipped in dry ice and should immediately be thawed or stored in liquid nitrogen upon receipt. Do not use a -80°C freezer for long term storage.

Supplied As: Each vial contains ˃1 x 106 cells in 1 ml of Cell Freezing Medium (BPS Bioscience #79796)

Target: B2M

Uniprot: P61769

Warnings: Avoid freeze/thaw cycles.

Biosafety Level: BSL-1

• Artikelnummer: BPS82871
• Hersteller: BPS Bioscience
• Hersteller Artikelnummer: 82871
• Verpackungseinheit: 2 vials
• Mengeneinheit: PAK