Product Description: Baloxavir marboxil (S-033188) is a selective inhibitor of influenza cap-dependent endonuclease. Baloxavir marboxil, a potent antiviral agent, shows activity against influenza A and B virus[1].
Applications: COVID-19-anti-virus
Formula: C27H23F2N3O7S
Citations: Antimicrob Agents Chemother. 2020 Jun 23;64(7):e00222-20./Euro Surveill. 2019 Mar;24(12):1900170./Front Microbiol. 2021 Feb 12;12:611958./J Virol. 2021 Apr 14;JVI0040821./Viruses. 2023 Dec 16, 15(12), 2444./Antimicrob Agents Chemother. 2021 Aug 23;AAC0113721./Antimicrob Agents Chemother. 2022 Mar 9;e0000922./Antivir Res. 2020 Jun;178:104786./Antiviral Res. 2024 Jul 8:105959./Bioorg Chem. 1 October 2021, 105388./Chem Biodivers. 2024 Nov 24:e202402465./Emerg Infect Dis. 2019 Nov;25(11):2108-2111. /Front Microbiol. 2018 Dec 6;9:3026./Front Pharmacol. 2019 Oct 16;10:1203./J Antimicrob Chemother. 2020 Dec 22;dkaa527./J Biol Chem. 2021 Feb 26;100486./J Ethnopharmacol. 2024 Nov 9:119091./J Infect Dis. 2023 Sep 28:jiad418./J Virol. 2020 Oct 27;94(22):e00319-20./Microorganisms. 2020, 8(12), 1968./Mol Pharm. 2022 Oct 21./Nat Commun. 2020 Jan 9;11(1):164. /Nat Microbiol. 2020 Jan;5(1):27-33./Pathogens. 2020 Sep 2;9(9):725./PLoS Pathog. 2022 Jul 13;18(7):e1010698./Proc Natl Acad Sci U S A. 2020 Apr 14;117(15):8593-8601./SSRN. 2024 Apr 30./SSRN. 2024 Aug 7./The Division of Medical Sciences,Harvard University. 2019 Dec./University of Alberta . Department of Medical Microbiology and Immunology. 2022 Jan./Virus Res. 345, July 2024, 199371./Viruses. 2024 Sep 14.
References: [1]Frederick G Hayden, et al. Baloxavir Marboxil for Uncomplicated Influenza in Adults and Adolescents. N Engl J Med. 2018 Sep 6;379(10):913-923./[2]Hideyuki Ikematsu, et al. Baloxavir Marboxil for Prophylaxis against Influenza in Household Contacts. N Engl J Med. 2020 Jul 23;383(4):309-320.
CAS Number: 1985606-14-1
Molecular Weight: 571.55
Compound Purity: 99.98
Research Area: Infection; Cancer
Solubility: DMSO : 33.33 mg/mL (ultrasonic)
Target: Influenza Virus
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