Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: N,N-dimethyl-carbamic acid-3-[[(dimethylamino)carbonyl]oxy]-5-[2-[(1,1-dimethylethyl)amino]-1-hydroxyethyl]phenyl ester, monohydrochloride
Purity: ≥95%
Formula Markup: C18H29N3O5 / HCl
Formula Weight: 403.9
CAS Number: 81732-46-9
Notes: Bambuterol is a prodrug form of the β-adrenergic receptor (β-AR) agonist terbutaline (Item No. 29337).{29051,25395} It is also an inhibitor of butyrylcholinesterase (BChE; IC50 = 3.9 nM for the human enzyme), the enzyme that metabolizes bambuterol into terbutaline, and this inhibition increases the duration of action of terbutaline.{29051,57423} Bambuterol (1 and 2 mg/kg) increases the latency to histamine-induced collapse in guinea pigs.{57422} It completely inhibits ovalbumin-induced decreases in dynamic compliance and increases in pulmonary resistance in ovalbumin-sensitized guinea pigs when administered at a dose of 10 mg/kg. Formulations containing bambuterol have been used in the treatment of asthma.
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