Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: N,N'-[1,2-ethanediylbis(oxy-2,1-phenylene)]bis[N-[2-[(acetyloxy)methoxy]-2-oxoethyl]-1,1'-bis[(acetyloxy)methyl] ester-glycine
Purity: ≥98%
Formula Markup: C34H40N2O18
Formula Weight: 764.7
CAS Number: 126150-97-8
Notes: BAPTA (Item No. 11706) is membrane-impermeable calcium chelator that binds extracellular calcium ions (Kd = 0.11 μM), with selectivity over magnesium ions or protons.{22804,23059} BAPTA and its derivatives can also be used as calcium indicators, since the absorption maximum for BAPTA changes when it is complexed with calcium (absorption maxima free/complexed = 254/274 nm, emission maxima free/complexed = 363/363 nm).{25230} BAPTA AM is a cell permeable analog of BAPTA that binds calcium only after the acetoxymethyl group is removed by cytoplasmic esterases.{25228} It is commonly used at 10-100 μM to evaluate the role of intracellular calcium in cell signaling.{25229,25228,25226,25225} It can also be used in animals.{25228} BAPTA AM also inhibits voltage-gated potassium (Kv) channels, including Kv1.3, Kv1.5, and Kv11.1 (Ki = 1.45, 1.23, and 1.30 μM, respectively).{25227}
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