Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: 2,3,4,5,6-pentafluoro-N-(3-fluoro-4-methoxyphenyl)-benzenesulfonamide, monosodium salt
Purity: ≥98%
Formula Markup: C13H6F6NO3S / Na
Formula Weight: 393.237869
CAS Number: 195533-98-3
Notes: Batabulin is an inhibitor of tubulin polymerization.{59889} It covalently binds to cysteine 239 (Cys239) of the β1, β2, and β4 tubulin isotypes and inhibits polymerization of bovine brain tubulin (IC50 = 2 µM) in cell-free assays. Batabulin (30, 100, and 300 nM) induces cytoskeletal collapse and cell cycle arrest at the G2/M phase in MCF-7 breast cancer cells. It is cytotoxic against a panel of drug-sensitive and -resistant cancer cell lines (IC50s = 11-165 nM). Batabulin (40 mg/kg) reduces tumor volume in CCRF CEM lymphoblastic leukemia and CEM/VBL100 multidrug-resistant lymphoblastic leukemia mouse xenograft models.
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