BAY-3827, CAS 2377576-35-5

Product Description: BAY-3827 is a potent and selective AMPK inhibitor with IC50 values of 1.4 nM at low (10 μM ATP concentration) and 15 nM at high (2 mM ATP concentration). BAY-3827 shows over 500-fold selectivity for most of the 331 kinases. BAY-3827 prevents phosphorylation of acetyl-CoA carboxylase 1 and shows strongest anti-proliferative activity in androgen-dependent prostate cancer cell lines[1].

Applications: Cancer-Kinase/protease

Formula: C27H25FN6O

References: [1]Lemos C, et al. The potent AMPK inhibitor BAY-3827 shows strong efficacy in androgen-dependent prostate cancer models. Cell Oncol (Dordr). 2021 Jun;44(3):581-594.

CAS Number: 2377576-35-5

Molecular Weight: 468.53

Compound Purity: 99.66

Research Area: Cancer

Solubility: DMSO : 25 mg/mL (ultrasonic;warming;heat to 60°C)

Target: AMPK

• Artikelnummer: MEXHY-112083-5
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-112083-5
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK