Product Description: BAY-899 is an orally active and selective luteinizing hormone receptor (LH-R) antagonist with IC50s of 185 nM and 46nM for hLH (human LH) and rLH (rat LH), respectively. BAY-899 can reduce sex hormone levels[1].
Applications: Metabolism-protein/nucleotide metabolism
Formula: C25H19F2N5O2
References: [1]Wortmann L, et al. Discovery of BAY-298 and BAY-899: Tetrahydro-1,6-naphthyridine-Based, Potent and Selective Antagonists of the Luteinizing Hormone Receptor Which Reduce Sex Hormone Levels In Vivo. J Med Chem. 2019 Oct 31.
CAS Number: 2471967-92-5
Molecular Weight: 459.45
Compound Purity: 99.93
Research Area: Endocrinology
Solubility: DMSO : 130 mg/mL (ultrasonic)
Target: GnRH Receptor