Product Description: BD-1047 (dihydrobromide) is a selective functional antagonist of sigma-1 receptor, shows antipsychotic activity in animal models predictive of efficacy in schizophrenia[1].
Applications: Neuroscience-Neurodegeneration
Formula: C13H22Br2Cl2N2
Citations: Cell Rep. 2023 Jan 31;42(1):112011./Eur J Pharmacol. 2023 Mar 8;175647./Int Immunopharmacol. 2023 Dec 22:127:111382./Int Immunopharmacol. 2023 Feb 22;117:109907./Mol Med. 2022 Aug 3;28(1):87./Neural Regen Res. 2024 Apr 3./Life Sci. 2020 Sep 15;257:118047.
References: [1]Skuza G, et al. Effect of BD 1047, a sigma1 receptor antagonist, in the animal models predictive of antipsychotic activity. Pharmacol Rep. 2006 Sep-Oct;58(5):626-635./[2]Shimazawa M, et al. Effect of a sigma-1 receptor agonist, cutamesine dihydrochloride (SA4503), on photoreceptor cell death against light-induced damage. Exp Eye Res. 2015 Mar;132:64-72./[3]Rogóz Z, et al. Mechanism of synergistic action following co-treatment with pramipexole and fluoxetine or sertraline in the forced swimming test in rats. Pharmacol Rep. 2006 Jul-Aug;58(4):493-500.
CAS Number: 138356-21-5
Molecular Weight: 437.04
Compound Purity: 98.14
Research Area: Neurological Disease
Solubility: DMSO : 25 mg/mL (ultrasonic)/H2O : 25 mg/mL (ultrasonic)
Target: Sigma Receptor
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