Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 2-((S)-3-(((S)-1-ethoxy-1-oxo-4-(phenyl-d5)butan-2-yl)amino)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-1-yl)acetic acid, monohydrochloride
Purity: ≥99% deuterated forms (d1-d5)
Formula Markup: C24H23D5N2O5 / HCl
Formula Weight: 465.98054
CAS Number: 1279026-26-4
Notes: Benazepril-d5 is intended for use as an internal standard for the quantification of benazepril (Item No. 23804). Benazepril is a prodrug of the angiotensin converting enzyme (ACE) inhibitor benazeprilat (Item No. 21796).{38021} It is metabolized to benazeprilat by hepatic esterases. Benazepril inhibits the in vitro enzymatic activity of partially purified ACE isolated from rabbit lung (IC50 = 2 nM).{26178} It decreases the triglyceride and total cholesterol levels in normotensive rats when administered at a dose of 30 mg/kg and decreases aortic atherosclerosis in cholesterol-fed rabbits when administered at a dose of 3 mg/kg per day.{41556} Benazepril (0.1-10 mg/kg per day) reduces blood pressure in spontaneously hypertensive rats.{41557} It also decreases proteinuria in cats with chronic kidney disease when administered at doses ranging from 0.5 to 1 mg/kg per day.{41558} Formulations containing benazepril have been used to treat hypertension, congestive heart failure, and chronic kidney disease in both human and veterinary medicine.
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