Description: Beta-2 microglobulin is a component of the class I major histocompatibility complex (MHC I) where it functions in antigen processing and presentation. Involved in the presentation of peptide antigens to the immune system. Human Beta-2 microglobulin is expressed on many types of cells including lymphocytes, thymocytes, monocytes, granulocytes, platelets, endothelial cells, and epithelial cells. It is absent on erythrocytes. This MAb is specific to human Beta-2 microglobulin and does not react with non-human primate cells. This antibody reacts with all cell types excluding erythrocytes. The detection of Beta-2 microglobulin in body fluids has been used as a tumor marker and for monitoring patients with HIV infection. Clone 246 E9.E7 is the same as HLA.ABC.m2.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
Product Origin: Animal - Mus musculus (mouse), Bos taurus (bovine)
Conjugate: CF740
Concentration: 0.1 mg/mL
Storage buffer: PBS, 0.1% rBSA, 0.05% azide
Clone: 246-E9.E7/same as HLA.ABC.m2
Immunogen: Human PBLs from a T-cell acute lymphoblastic leukemia (T-ALL) patient
Antibody Reactivity: Beta-2 Microglobulin
References: Note: References for this clone sold by other suppliers may be listed for expected applications.
- J Histochem Cytochem (1985) 33(12): 1183-1189. (IF)
- Immunol Cell Biol (1988) 66 (Pt 1) 69-77. (platelet aggregation)
- Br J Cancer (1992) 66: 88-92. (IP)
Entrez Gene ID: 567
Expected AB Applications: Flow, surface (published for clone)/Functional studies (published for clone)/IF (published for clone)/IP (published for clone)
Z-Antibody Applications: Flow, surface (published)/IF (published)/Functional studies (published)/IP (published)
Antibody Application Notes: Higher concentration may be required for direct detection using primary antibody conjugates than for indirect detection with secondary antibody/Immunofluorescence: 0.5-1 ug/mL/Does not react with non-human primates; others not known/Flow Cytometry 0.5-1 ug/million cells/0.1 mL/Optimal dilution for a specific application should be determined by user
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