Bexarotene, CAS 153559-49-0

Retinoid RXR agonist

Product Type: Agonist

CAS No.: 153559-49-0

MolecularFormula: C24H28O2

Molecular Weight: 348,5

Source: Synthetic

Purity: >98% (TLC); NMR (Conforms)

Solubility: Soluble in DMSO (60 mg/ml) or ethanol (warm, 10 mg/ml)

Appearance: White powder

PubChem CID: 82146

Scientific Background: Bexarotene is a highly potent and selective retinoid X receptor (RXR) agonist (1). Clinically useful antineoplastic agent for cutaneous T-cell lymphoma (2) Causes complete regression of mammary carcinoma (3). Bexarotene significantly increases clearance of soluble β-amyloid in a mouse Alzheimer′s model and increases cognitive ability (4). Reverses apoE4-driven brain pathology and behavioral deficits in vivo (5).

References: 1.MF Boehm et al. J. Med. Chem. 1995 38:31462.R Gniadecki et al. Br. J. Dermatol. 2007 157:4333.ED Bischoff et al. Cancer Res. 1998 58:4794.PE Cramer et al. Science 2012 335:15035.A Boehm-Cagan and DM Michaelson J. Neurosci. 2014 34:7293

Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• Artikelnummer: STRSIH-535-100MG
• Hersteller: Stressmarq Biosciences
• Hersteller Artikelnummer: SIH-535-100MG
• Verpackungseinheit: 100 mg
• Mengeneinheit: STK