Shelf life (days): 365.0
Formulation: Lyophilized from sterile PBS, pH 7.4
Uniprot ID: Q16548
Purity: ≥85% estimated by SDS-PAGE
Formula Weight: 0.0
Notes: Bfl-1, also known as Bcl-2-related protein A1 (Bcl-2A1), is an anti-apoptotic member of the Bcl-2 family of proteins.{32900} It is composed of two Bcl-2 homology (BH) domains (BH1 and BH2), which facilitate binding to Bim, Bid, PUMA, and Noxa, putative BH3 and BH4 domains, and a C-terminal region that regulates localization and function.{32900,72465} Bfl-1 expression can be induced by cytokines such as IL-1β and TNF-α and is primarily expressed in leukocytes, the spleen, and the lungs but is also expressed in the small intestine, testis, and thymus and localizes to the mitochondria.{72466,72467} However, a short splice variant, Bfl-1S, localizes to the nucleus.{72468} Bfl-1 is involved in p53-dependent apoptosis and autophagy.{72465,72469} Ectopic overexpression of BCL2A1 induces resistance to the Bcl-2 inhibitor venetoclax (ABT-199; Item No. 16233) in cancer cells, and Bfl-1 is overexpressed in several cancers.{72470,72471} Cayman’s Bfl-1 (human, recombinant) protein consists of 170 amino acids and has a calculated molecular weight of 19.7 kDa.
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