BI-847325, CAS 1207293-36-4

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: 3-[3-[[[4-[(dimethylamino)methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-2-oxo-1H-indol-6-yl]-N-ethyl-2-propynamide

Purity: ≥98%

Formula Markup: C29H28N4O2

Formula Weight: 464.6

CAS Number: 1207293-36-4

Notes: BI-847325 is a selective dual MEK/Aurora kinase inhibitor with IC50 values of 3, 25, 15, 25, and 4 nM for X. laevis Aurora B, human Aurora A and Aurora C, and human MEK1 and MEK2, respectively.{29630} It can inhibit the growth and survival of both treatment-naive and drug-resistant melanoma cell lines, decreasing the expression of MEK and Mcl-1 while increasing the expression of pro-apoptotic protein Bim.{29630} At 70 mg/kg, BI-847325 induces apoptosis in treatment-naive and drug-resistant xenografted melanoma in vivo.{29630}

• Artikelnummer: CAY18301-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 18301-1
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK