Bicuculline methiodide, CAS 40709-69-1

Bicuculline methiodide, CAS 40709-69-1
Artikelnummer
MEXHY-103474-5
Verpackungseinheit
5 mg
Hersteller
MedChemExpress

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Product Description: Bicuculline methiodide is a potent GABA(A) receptors blocker. Bicuculline methiodide alters membrane properties and firing pattern. Bicuculline methiodide reduces the Apamin-sensitive afterhyperpolarization, while Apamin is a toxin isolated from bee venom to block small conductance Ca2+ -activated K+ channels. Bicuculline methiodide facilitates burst firing via blocking apamin-sensitive Ca2+ -activated K+ current[1].

Applications: Neuroscience-Neurodegeneration

Formula: C21H20INO6

Citations: bioRxiv. 2024 November 26./Brain Behav Immun. 2019 Nov;82:45-62. /Acta Pharmacol Sin. 2024 Jun 11./Adv Sci (Weinh). 2024 Dec 16:e2407387./Biomedicines. 2021, 9(9), 1118./bioRxiv. 2023 Jul 6./BMC Immunol. 2022 Nov 25;23(1):58./Brain Behav Immun. 2023 Jun 5;S0889-1591(23)00141-1./Cell Rep. 2021 Jul 20;36(3):109398./Cell Rep. 2023 Nov 17;42(12):113467./Cell. 2023 Mar 30;186(7):1352-1368.e18./Clin Exp Hypertens. 2022 Jan 7;1-12./Immunity. 2024 Mar 12;57(3):495-512.e11./Int J Mol Sci. 2022, 23(19), 11210./J Adv Res. 2023 Jun 21;S2090-1232(23)00171-6./J Agric Food Chem. 2024 Mar 27;72(12):6189-6202./J Neuroendocrinol. 2020 Jun;32(6):e12876./J Pain. 2019 May;20(5):577-591. /J Psychiatr Res. 2023 May 17;163:180-194./Life Sci. 2024 Dec 3:123290./Neural Regen Res. 2022 Jan;17(1):178-184./Neurobiol Dis. 2023 May 12;106155./Research Square Preprint. 2024 Oct 08./Research Square Print. August 24th, 2022./Research Square Print. September 19th, 2022./Sci Rep. 2024 Dec 28;14(1):31388./Theranostics. 2022; 12(7):3057-3078.

References: [1]Johnson SW, et al. Bicuculline methiodide potentiates NMDA-dependent burst firing in rat dopamine neurons by blocking apamin-sensitive Ca2+-activated K+ currents. Neurosci Lett. 1997 Aug 1;231(1):13-6. /[2]Yang Y, et al. Ketamine blocks bursting in the lateral habenula to rapidly relieve depression[J]. Nature, 2018, 554(7692): 317-322.

CAS Number: 40709-69-1

Molecular Weight: 509.29

Compound Purity: 99.24

Research Area: Neurological Disease

Solubility: DMSO : 150 mg/mL (ultrasonic)

Target: GABA Receptor
Mehr Informationen
Artikelnummer MEXHY-103474-5
Hersteller MedChemExpress
Hersteller Artikelnummer HY-103474-5
Verpackungseinheit 5 mg
Mengeneinheit STK
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