Bitopertin, CAS 845614-11-1

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: [4-[3-fluoro-5-(trifluoromethyl)-2-pyridinyl]-1-piperazinyl][5-(methylsulfonyl)-2-[(1S)-2,2,2-trifluoro-1-methylethoxy]phenyl]-methanone

Purity: ≥98%

Formula Markup: C21H20F7N3O4S

Formula Weight: 543.5

CAS Number: 845614-11-1

Notes: Bitopertin is an inhibitor of glycine transporter 1 (GlyT1; IC50 = 0.03 µM).{64310} It is selective for GlyT1 over GlyT2 (IC50 = >30 µM) as well as a panel of 107 receptors, transporters, and enzymes at 10 µM.{64310,64309} Bitopertin (0.1 µM) increases long-term potentiation in rat hippocampal CA1 slices.{64309} It reverses hyperlocomotion induced by the NMDA receptor partial agonist L-687,414 in mice (ID50 = 0.5 mg/kg).{64310}

• Artikelnummer: CAY19896-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 19896-10
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK