BIX02188, CAS 334949-59-6

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: (3Z)-3-[[[3-[(dimethylamino)methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-2-oxo-1H-indole-6-carboxamide

Purity: ≥95%

Formula Markup: C25H24N4O2

Formula Weight: 412.5

CAS Number: 334949-59-6

Notes: BIX02188 is a potent inhibitor of MEK5 (IC50 = 4.3 nM) with reduced activity towards inhibition of ERK5 and TGFβR1 (IC50s = 810 and 1,800 nM, respectively).{27914} It does not inhibit the closely related kinases MEK1, MEK2, ERK2, and JNK2 (IC50s = > 6,300 nM).{27914} BIX02188 inhibits phosphorylation of ERK5 in a dose-dependent manner without affecting phosphorylation of ERK1/2, p38 MAPK, or JNK1/2.{27914}

• Artikelnummer: CAY16238-25
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 16238-25
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK