Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: 1-[[1,5-bis(4-chlorophenyl)-2-methyl-1H-pyrrol-3-yl]methyl]-4-methyl-piperazine
Purity: ≥98%
Formula Markup: C23H25Cl2N3
Formula Weight: 414.4
CAS Number: 146204-42-4
Notes: BM212 is an antimycobacterial compound.{37196} It inhibits the growth of laboratory and clinical isolate M. tuberculosis strains (MICs = 0.7-1.5 μg/ml), including strains resistant to ethambutol (Item No. 23713), isoniazid (Item No. 20378), rifampicin (Item No. 14423), and rifabutin (Item No. 16468). BM212 also inhibits the growth of M. fortuitum, M. smegmatis, M. kansasii, and M. avium strains (MICs = 3.1-12.5, 3.1-25, 3.1-6.2, and 0.4-3.1 μg/ml, respectively). It inhibits replication of intracellular M. tuberculosis in infected U937 macrophages in a dose-dependent manner at concentrations ranging from 0.5-10 μg/ml. Some M. smegmatis, M. bovis BCG, and M. tuberculosis H37Rv mutant strains carry mutations in the mycobacterium membrane protein large 3 (mmpL3) gene and are resistant to BM212, indicating mmpL3 is likely a cellular target of BM212.{37197}
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