BMH-22, CAS 309726-06-5

Product Description: BMH-22, a benzonaphthyridin, is a RNA polymerase I (Pol I) transcription inhibitor independent of p53 function. BMH-22 causes reorganization of nucleolar marker proteins consistent with segregation of the nucleolus. BMH-22 destabilizes RPA194 in a proteasome-dependent manner and inhibits nascent rRNA synthesis and expression of the 45S rRNA precursor. BMH-22 shows potent anticancer activity across many tumor types[1].

Applications: Cancer-programmed cell death

Formula: C16H17N3

References: [1]RPA194, rRNA synthesis, 45S Rrna, anticancerKarita Peltonen, et al. Small molecule BMH-compounds that inhibit RNA polymerase I and cause nucleolar stress. Mol Cancer Ther. 2014 Nov;13(11):2537-46.

CAS Number: 309726-06-5

Molecular Weight: 251.33

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: DNA/RNA Synthesis

• Artikelnummer: MEXHY-118723-5
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-118723-5
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK