Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: 4-[(1E)-2-(5,6-dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl)ethenyl], benzoic acid
Purity: ≥98%
Formula Markup: C27H24O2
Formula Weight: 380.5
CAS Number: 166977-43-1
Notes: Nuclear retinoic acid receptors (RARs) are transcriptional regulators with roles in cell proliferation and differentiation. BMS 453 is a synthetic retinoid that acts as an agonist of RARβ and an antagonist of RARα and RARγ.{30780} It has been shown to inhibit the proliferation of normal breast cells via the induction of TGF-β activity, causing G1 arrest.{30782} BMS 453 binding to RARα and RARγ can induce a transrepression of phorbol ester-induced AP-1 activity (IC50s = ~0.1 nM in HeLa and MCSF-7 cells), which also correlates with reduced cell proliferation.{30780} BM 453 has been used to trigger the differentiation of mouse embryonic stem cells (mES) in a study of RARβ-induced mES cell adipogenesis.{30781}
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