Product Description: BMVC is a potent G-quadruplex (G4) stabilizer and a selective telomerase inhibitor with an IC50 of ~0.2 μM. BMVC inhibits Taq DNA polymerase with an IC50 of ~2.5 μM. BMVC increases the melting temperature of G4 structure of telomere and accelerates telomere length shortening. Anticancer activities[1][2].
Applications: Cancer-programmed cell death
Formula: C28H25I2N3
References: [1]Huang FC, et al. G-quadruplex stabilizer 3,6-bis(1-methyl-4-vinylpyridinium)carbazole diiodide induces accelerated senescence and inhibits tumorigenic properties in cancer cells. Mol Cancer Res. 2008 Jun;6(6):955-64./[2]Jen-Fei Chu, et al. A Novel Method for Screening G-quadruplex Stabilizers to Human Telomeres. Journal of the Chinese Chemical Society, 2011, 58, 296-300.
CAS Number: 627810-06-4
Molecular Weight: 657.33
Compound Purity: 99.92
Research Area: Cancer
Solubility: DMSO : 10 mg/mL (ultrasonic;warming;heat to 60°C)
Target: DNA/RNA Synthesis;G-quadruplex;Telomerase
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