Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: 3S-[[(1,1-dimethylethoxy)carbonyl]amino]-5-fluoro-4-oxo-pentanoic acid, methyl ester
Purity: ≥95%
Formula Markup: C11H18FNO5
Formula Weight: 263.3
CAS Number: 187389-53-3
Notes: Boc-D-FMK is a cell-permeable, irreversible pan-caspase inhibitor.{26387,26384} Also known as Boc-D(OMe)-FMK, this compound contains a methyl ester group, which facilitates uptake by cells and subsequently is removed by cytoplasmic esterases, leaving the functional inhibitor. Boc-D-FMK blocks apoptosis stimulated by TNF-α in neutrophils (IC50 = 39 µM), by bile duct ligation in hepatocytes, and by TNF-α in renal endothelial cells.{26383,26385,26386} The FMK pharmacophore is known to interact with non-caspase cysteine proteases, presumably explaining why Boc-D-FMK also inhibits cathepsins H and L.{26387}
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