Product Description: BRD7552, a potent PDX1 transcription factor inducer, upregulates PDX1 expression in both primary human islets and ductal cells, and induces epigenetic changes in the PDX1 promoter consistent with transcriptional activation. BRD7552 increases insulin expression. PDX1 is a key transcription factor involved in pancreas development and β cell function[1].
Formula: C33H33N3O15
References: [1]Yuan Y, et al. A small-molecule inducer of PDX1 expression identified by high-throughput screening [published correction appears in Chem Biol. 2014 Feb 20;21(2):306]. Chem Biol. 2013;20(12):1513-1522.
CAS Number: 1137359-47-7
Molecular Weight: 711.63
Compound Purity: 99.32
Research Area: Endocrinology
Solubility: DMSO : 100 mg/mL (ultrasonic)
Target: Others